Distribution is the second step in drug pharmacokinetics. Pharmacokinetics refers to how a drug is processed by the body. Volume of distribution is a way to quantify the extent of drug distribution throughout the body. Intravascular & Extravascular Spaces The body can be broadly divided into intravascular and extravascular spaces. Intravascular space refers to anyContinue reading “Volume of Distribution: Why We Need it and How to Use It”
Tag Archives: weight-loss
Pharmacokinetics of Absorption: 3 Metabolic Processes that Affect Bioavailability
First Pass Effect, Enterohepatic Recirculation and P glycoproteins Drug absorption is the first important step needed for a drug to impact the body. The first pass effect, enterohepatic recirculation and p glycoproteins determine how much of the absorbed drug gets to the site of action. When we develop a dosing regimen, we consider how muchContinue reading “Pharmacokinetics of Absorption: 3 Metabolic Processes that Affect Bioavailability”