Distribution is the second step in drug pharmacokinetics. Pharmacokinetics refers to how a drug is processed by the body. Volume of distribution is a way to quantify the extent of drug distribution throughout the body. Intravascular & Extravascular Spaces The body can be broadly divided into intravascular and extravascular spaces. Intravascular space refers to anyContinue reading “Volume of Distribution: Why We Need it and How to Use It”
Category Archives: Pharmacokinetics
Pharmacokinetics of Absorption: 3 Metabolic Processes that Affect Bioavailability
First Pass Effect, Enterohepatic Recirculation and P glycoproteins Drug absorption is the first important step needed for a drug to impact the body. The first pass effect, enterohepatic recirculation and p glycoproteins determine how much of the absorbed drug gets to the site of action. When we develop a dosing regimen, we consider how muchContinue reading “Pharmacokinetics of Absorption: 3 Metabolic Processes that Affect Bioavailability”
Cytochrome Enzymes and Glycoproteins: What You need to Know
Cytochrome P450 (CYP) enzymes play a crucial role in metabolizing over 70% of clinical drugs, primarily in the liver. P-Glycoproteins (PGP) help pump foreign substances out of cells. Drug interactions with these proteins can lead to toxicity or reduced efficacy. Clinically significant drugs may induce or inhibit these proteins, requiring careful monitoring for interactions.